Title: Label-free Cancer Cell Classification via Time-stretch Imaging with Optical Data Compression

Speaker: Prof. Bahram Jalali (UCLA, Fellows of IEEE, OSA, APS and SPIE)  

Time: June 25, 2015 09:30AM

Venue: No. 101 Meeting Room, IOS, CAS

Abstract: Real-time instruments that acquire large data sets are needed for detection and classification of outliers. A new class of high throughput real-time instruments based on the photonic time-stretch has led to the discovery of optical rogue waves, detection of rare cancer cells, and the highest analog-to-digital conversion performance ever achieved. As an imaging flow-through microscope, the technology is in clinical testing for blood screening. While highly useful for collecting large data sets, the instrument’s ultrahigh throughput also creates a big data problem. The system produces a large volume of data in a short time equivalent to several 4K movies per second. Such a data fire hose places a burden on data acquisition, storage, and processing operations and calls for technologies that compress images in optical domain and in real-time. An example of this, based on warped stretch transformation and non-uniform Fourier domain sampling has recently been reported. The talk will provide an overview of the time-stretch microscope with real-time optical image compression, and application of this technology in label-free classification of cancer cell lines in blood via machine learning.

Biography: Prof. Jalali is the Northrop-Grumman Endowed Chair and Professor of Electrical Engineering at UCLA with joint appointments in Biomedical Engineering, California NanoSystems Institute (CNSI) and Department of Surgery at the UCLA School of Medicine. He received his Ph.D. in Applied Physics from Columbia University in 1989 and was with Bell Laboratories in Murray Hill, New Jersey until 2002 before joining UCLA. He is a Fellow of IEEE, the Optical Society of America (OSA), the American Physical Society (APS) and SPIE. He is the recipient of the R.W. Wood Prize from Optical Society of America for the invention and demonstration of the first Silicon Laser, the Aron Kressel Award of the IEEE Photonics Society, the Achievement Medal from IET for his contributions to field of instrumentation for cancer detection, and the Distinguished Engineering Achievement Award from the Engineers Council. In 2005 he was elected into the Scientific American Top 50, and received the BrideGate 20 Award in 2001 for his entrepreneurial accomplishments and contributions to Southern California economy.